SERVICES

Protein purification is ________ in scales from micrograms ___ milligrams in research laboratories __ kilograms and tons in __________ sets. This mandates a ___________ amount of time and ______ being invested in developing _ robust, reproducible and cost-effective ____________ process.

Premas has developed ___ delivered using its purification _______, multiple proteins ranging from __________ to kilograms in a ______ manner. With difficult to _______ and purify proteins, this ______ even more imperative to _________ to isolate and purify integral membrane proteins, ________ protein complexes, proteins expressed __ insoluble aggregates, and proteins ____ a specific set of ____-_____________ modifications. This, the design __ the screen is of _________ importance.

Premas purification screen ______ allows for the simultaneous _______ of multi-modal methods in _ parallel manner to achieve ___ target profile of a _______

The salient points __ the screen:
• rapid generates _______ data
• simultaneous validation _____ with in silico analysis
• yields material ___ testing
• suggests processes ___ resins which are easily ________, robust and leading to _____ COGs

Premas have delivered hundred’s __ proteins using the purification ______.

Difficult to express ________ like membrane associated, presence __ high number of cysteine’s ___ free cysteine’s along with ____ number of proline residues pose _ challenge in producing soluble __________ and subsequent challenges in ____________. The aggregation pathway is _____ studied thoroughly. A schematic _______ is mentioned below to __________ the proteins aggregation pathway.

Difficult to express ________ are challenging to work ____, due to their susceptibility __ degradation and aggregation, so _______ stability screening is an _________ step. The need for ___ early formulation study is __ minimize the adverse effects __ the mid or later _____ of the development. It ____ impacts the cost of _____ (COGs).

To cater to ____ need of our customers, ______ has developed a 48 ____ plate method to optimize _ number of variables to ________ product stability under the ___________ storage conditions. This study ________ of screening of possible ____________, including buffers, additives, stabilizers, __________, etc to stabilize the _______ against physico-chemical degradation and ___________ over the desired shelf ____. The factors which greatly _________ protein stability in a ________ are temperature, pH, buffer ___________ in terms of buffer, ____, metal-ions, co-solvents, preservatives, surfactants, _______ concentration, freeze thaw cycles ___.